Publications about viruses

Our Lab has studied for several years the interactions between viruses and the immune system. Our main interests comprehend:

BKV (click here to see the publications)

Urine-derived renal tubular epithelial cells resemble functional characteristics of professional antigen-presenting cells and can directly induce BKV-specific T cell responses.

Roch T, Paniskaki K, Wehler P, Thieme CJ, Moradian H, Blazquez-Navarro A, Anft M, Reinke P, Westhoff TH, Stervbo U and Babel N.

(2025) J Nephrol. ; doi: https://doi.org/10.1007/s40620-025-02298-2

Differential Diagnosis of Interstitial Allograft Rejection and BKV Nephropathy by T-cell Receptor Sequencing.

Stervbo U, Nienen M, Hecht J, Viebahn R, Amann K, Westhoff TH and Babel N.

(2020) Transplantation. 104, e107-e108; doi: https://doi.org/10.1097/TP.0000000000003054

BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study.

Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, Bauer C, Wolk K, Sabat R, Westhoff TH, Sawitzki B, Reinke P, Thomusch O, Hugo C, Or-Guil M and Babel N.

(2018) EBioMedicine. 34, 113-121; doi: https://doi.org/10.1016/j.ebiom.2018.07.017

Differential T cell response against BK virus regulatory and structural antigens: A viral dynamics modelling approach.

Blazquez-Navarro A, Schachtner T, Stervbo U, Sefrin A, Stein M, Westhoff TH, Reinke P, Klipp E, Babel N, Neumann AU and Or-Guil M.

(2018) PLoS Comput Biol. 14, e1005998; doi: https://doi.org/e1005998

A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients.

Weist BJ, Wehler P, El Ahmad L, Schmueck-Henneresse M, Millward JM, Nienen M, Neumann AU, Reinke P and Babel N.

(2015) Kidney Int. 88, 1293-1303; doi: https://doi.org/10.1038/ki.2015.215

Different risk factor profiles distinguish early-onset from late-onset BKV-replication.

Schachtner T, Babel N and Reinke P.

(2015) Transpl Int. 28, 1081-91; doi: https://doi.org/10.1111/tri.12601

Inflammatory activation and recovering BKV-specific immunity correlate with self-limited BKV replication after renal transplantation.

Schachtner T, Stein M, Sefrin A, Babel N and Reinke P.

(2014) Transpl Int. 27, 290-301; doi: https://doi.org/10.1111/tri.12251

The genetic predisposition of natural killer cell to BK virus-associated nephropathy in renal transplant patients.

Trydzenskaya H, Juerchott K, Lachmann N, Kotsch K, Kunert K, Weist B, Schönemann C, Schindler R, Nickel P, Melzig MF, Hugo C, Thomusch O, Neumann AU, Reinke P and Babel N.

(2013) Kidney Int. 84, 359-65; doi: https://doi.org/10.1038/ki.2013.59

Mannose-binding lectin deficiency is not associated with increased risk for polyomavirus nephropathy.

Liman P, Babel N, Schachtner T, Unterwalder N, König J, Hofmann J, Reinke P and Nickel P.

(2012) Transpl Immunol. 26, 123-7; doi: https://doi.org/10.1016/j.trim.2011.12.004

Novel approach for improved assessment of phenotypic and functional characteristics of BKV-specific T-cell immunity.

Trydzenskaya H, Sattler A, Müller K, Schachtner T, Dang-Heine C, Friedrich P, Nickel P, Hoerstrup J, Schindler R, Thiel A, Melzig MF, Reinke P and Babel N.

(2011) Transplantation. 92, 1269-77; doi: https://doi.org/10.1097/TP.0b013e318234e0e5

BK polyomavirus infection and nephropathy: the virus-immune system interplay.

Babel N, Volk HD and Reinke P.

(2011) Nat Rev Nephrol. 7, 399-406; doi: https://doi.org/10.1038/nrneph.2011.59

BK-VP3 as a new target of cellular immunity in BK virus infection.

Mueller K, Schachtner T, Sattler A, Meier S, Friedrich P, Trydzenskaya H, Hinrichs C, Trappe R, Thiel A, Reinke P and Babel N.

(2011) Transplantation. 91, 100-7; doi: https://doi.org/

Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples.

Babel N, Fendt J, Karaivanov S, Bold G, Arnold S, Sefrin A, Lieske E, Hoffzimmer M, Dziubianau M, Bethke N, Meisel C, Grütz G and Reinke P.

(2009) Transplantation. 88, 89-95; doi: https://doi.org/10.1097/TP.0b013e3181aa8f62

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients.

Stervbo U, Nienen M, Weist BJD, Kuchenbecker L, Hecht J, Wehler P, Westhoff TH, Reinke P and Babel N.

(2019) Front Immunol. 10, 767; doi: https://doi.org/767

Interactions of TTV with BKV, CMV, EBV, and HHV-6A and their impact on post-transplant graft function in kidney transplant recipients.

Rosiewicz KS, Blazquez-Navarro A, Kaliszczyk S, Bauer C, Or-Guil M, Viebahn R, Zgoura P, Reinke P, Roch T, Hugo C, Westhoff T, Thieme C, Stervbo U and Babel N.

(2024) Front Transplant. 3, 1393838; doi: https://doi.org/1393838

High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort.

Blazquez-Navarro A, Roch T, Wehler P, Kaliszczyk S, Bauer C, Thieme C, Rosiewicz KS, Stervbo U, Anft M, Reinke P, Hugo C, Zgoura P, Viebahn R, Westhoff T, Or-Guil M and Babel N.

(2023) Front Transplant. 2, 1188535; doi: https://doi.org/1188535

CMV (click here to see the publications)

BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study.

Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, Bauer C, Wolk K, Sabat R, Westhoff TH, Sawitzki B, Reinke P, Thomusch O, Hugo C, Or-Guil M and Babel N.

(2018) EBioMedicine. 34, 113-121; doi: https://doi.org/10.1016/j.ebiom.2018.07.017

Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.

Stervbo U, Bozzetti C, Baron U, Jürchott K, Meier S, Mälzer JN, Nienen M, Olek S, Rachwalik D, Schulz AR, Neumann A, Babel N, Grützkau A and Thiel A.

(2015) Age (Dordr). 37, 93; doi: https://doi.org/93

Different risk factor profiles distinguish early-onset from late-onset BKV-replication.

Schachtner T, Babel N and Reinke P.

(2015) Transpl Int. 28, 1081-91; doi: https://doi.org/10.1111/tri.12601

Peripheral blood-derived virus-specific memory stem T cells mature to functional effector memory subsets with self-renewal potency.

Schmueck-Henneresse M, Sharaf R, Vogt K, Weist BJ, Landwehr-Kenzel S, Fuehrer H, Jurisch A, Babel N, Rooney CM, Reinke P and Volk HD.

(2015) J Immunol. 194, 5559-67; doi: https://doi.org/10.4049/jimmunol.1402090

High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function.

Nickel P, Bold G, Presber F, Biti D, Babel N, Kreutzer S, Pratschke J, Schönemann C, Kern F, Volk HD and Reinke P.

(2009) Transpl Immunol. 20, 238-42; doi: https://doi.org/10.1016/j.trim.2008.11.002

Clonotype analysis of cytomegalovirus-specific cytotoxic T lymphocytes.

Babel N, Brestrich G, Gondek LP, Sattler A, Wlodarski MW, Poliak N, Bethke N, Thiel A, Hammer MH, Reinke P and Maciejewski JP.

(2009) J Am Soc Nephrol. 20, 344-52; doi: https://doi.org/10.1681/ASN.2007111225

Treatment of cytomegalovirus disease with valganciclovir in renal transplant recipients: a single center experience.

Babel N, Gabdrakhmanova L, Juergensen JS, Eibl N, Hoerstrup J, Hammer M, Rosenberger C, Hoeflich C, Frei U, Rohde F, Volk HD and Reinke P.

(2004) Transplantation. 78, 283-5; doi: https://doi.org/

Sex-Associated Differences in Cytomegalovirus Prevention: Prophylactic Strategy is Potentially Associated With a Strong Kidney Function Impairment in Female Renal Transplant Patients.

Blazquez-Navarro A, Dang-Heine C, Bauer C, Wittenbrink N, Wolk K, Sabat R, Witzke O, Westhoff TH, Sawitzki B, Reinke P, Thomusch O, Hugo C, Babel N and Or-Guil M.

(2020) Front Pharmacol. 11, 534681; doi: https://doi.org/534681